Medicinal chemistry and chemical biology are rapidly expanding disciplines aiming at the understanding of important biological processes using organic chemistry. Both disciplines are cornerstones of the pharmaceutical industry and commonly driven by highly skilled multidisciplinary teams. In order to impact these competitive research areas as an academic, the Manetsch laboratory focuses on important and fundamental research ideas, which are considered to be risky and/or not profitable from an industry perspective.
The major research interests of the Manetsch laboratory consist of:
(a) Hit-to-lead optimization for neglected parasitic diseases.
(b) Development and application of a fragment-based screening platform termed kinetic Target-Guided Synthesis (TGS) targeting protein-protein interactions and other targets considered to be “undruggable”.
(c) Development of synthetic approaches for the straightforward preparation of compound series of interest.
(d) Development of specific probes or labeling tools for fluorescence or mass spectrometry based identification of relevant biomolecules
Over the years, the Manetsch laboratory was fortunate to establish strong collaborations with research groups significantly supporting ongoing and past research activities in the Manetsch laboratory:
John H. Adams, University of South Florida
Jeffrey Agar, Northeastern University
Jeremy N. Burrows, Medicines for Malaria Venture
Debopam Chakrabarti, University of Central Florida
Susan A. Charman, Monash University
James Duffy, Medicines for Malaria Venture
Jean-Claude Dujardin, Institute of Tropical Medicine, Antwerp
Gloria A. Ferreira, University of South Florida
David M. Floyd, Rutgers
Frank R. Fonczek, Louisiana State University
Wayne C. Guida, University of South Florida
R. Kip Guy, St. Jude Children's Research Hospital
James E. Kirby, Beth Israel Deaconess Medical Center / Harvard Medical School
Spencer Knapp, Rutgers
Dennis E. Kyle, University of South Florida
Randy W. Larsen, University of South Florida
David J. Merkler, University of South Florida
Lindsey N. Shaw, University of South Florida
Stanley Stevens, University of South Florida
Zhuo (Michael) Wang, University of Kansas
Hong-Gang Wang, Pennsylvania State University
Karl A. Werbovetz, Ohio State University
Paul Willis, Medicines for Malaria Venture
Lukasz Wojtas, University of South Florida