The Manetsch laboratory is interest in the discovery and optimization of chemical reactions enabling the straightforward preparation of compounds with interesting activities or properties. For hit-to-lead optimizations, kinetic target-guided synthesis, as well as the preparation of probe molecules, the development of new synthetic protocols have been instrumental.
Metal-Free Arylation of Ethyl Acetoacetate with Hypervalent Diaryliodonium Salts: an Immediate Access to Diverse 3-Aryl-4(1H)-Quinolones
Monastyrskyi A, Namelikonda N K, Manetsch R. J Org Chem 2014; 80, 2513-2502
Kumar, A. B.; Manetsch, R. European J. Org. Chem. 2014, 3551–3555.
Kulkarni, S. S.; Hu, X.; Manetsch, R. Chem. Commun. (Camb).2013, 49, 1193–1195.
Namelikonda, N. K.; Manetsch, R. Chem. Commun. (Camb).2012, 48, 1526–1528.
Cross, R. M.; Manetsch, R. J. Org. Chem.2010, 75, 8654–8657.